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KMID : 1137820220430020071
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의공학회지
2022 Volume.43 No. 2 p.71 ~ p.80
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Interaction between Particle with Dual Ligand and Cell under Flow
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Yoon Jung-Hyun
Lee Sei-Young
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Abstract
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The interaction between dual-ligand decorated particle-based delivery system and target cell under shear flow is predicted using probability model developed. We assumed the two kinds of ligand are decorated on the surface of the particle with 10% length difference. Fixed with other biophysical parameters, a study on the particle-cell inter- action for the different non-specific interaction parameter is performed. To induce the firm adhesion, short ligand- receptor should be engaged. Also, it is shown that the rational design of ligand-receptor interaction, including receptor number, specific interaction parameter, kinds of ligand-receptor, etc., should be considered.
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KEYWORD
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Particle-based delivery system, Non-specific interaction, Dual-ligand targeting, Probability of adhesion
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